Serum differentially alters the antifungal properties of echinocandin drugs.
نویسندگان
چکیده
Antifungal efficacies of the echinocandin drugs caspofungin, micafungin, and anidulafungin were reduced significantly in the presence of 50% human serum, which yielded nearly equivalent MICs or minimum effective concentrations against diverse Candida spp. and Aspergillus spp. Consistent with a direct drug interaction, serum decreased the sensitivity of glucan synthase to echinocandin drugs.
منابع مشابه
CD101: a novel long‐acting echinocandin
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عنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 51 6 شماره
صفحات -
تاریخ انتشار 2007